Symptoms: Severe hypotension, cardiac dysrhythmias, shock, CHF, pulmonary oedema, convulsions, and CNS depression, including coma; adjustments in ECG. Multi-drug overdoses involving gabapentin, particularly together with other CNS depressants reminiscent of opioids, may end up in coma and demise – this possibility ought to be thought-about when managing overdosage. The Tmax of gabapentin has been estimated to be 2-3 hours. The elimination t1/2 of gabapentin in patients with normal renal function is 5-7 hours. Approximately one-third of a single orally administered dose is excreted in urine within 24 hours. Maintenance dose is 900 mg day by day (body weight 26-36 Kg) or 1.2 gm day by day (body weight 37-50 Kg). For 3-12 years: 10 to 15 mg/kg, Incase of titration 25-35 mg/kg day by day in 3 divided doses. One research mentions a mean half-life of about 39 hours. This drug undergoes first-move metabolism and its plasma concentrations are attained inside 7 to 8.5 hours after oral administration. The obvious quantity of distribution of gabapentin after IV administration is 58±6 L. The drug is discovered within the CSF in concentrations roughly 9-20% of the corresponding plasma concentrations and is secreted into breast milk in concentrations similar to that seen in plasma.


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